Para uso exclusivo em pesquisa laboratorial. Não destinado ao consumo humano. Não destinado a uso clínico ou terapêutico. Não avaliado pela FDA.
Incretin
Também conhecido como: GIP, GLP-1, incretin hormone
Incretins are gut-derived hormones — principally GIP and GLP-1 — that potentiate glucose-dependent insulin signaling. Synthetic incretin-receptor agonists are studied in vitro for receptor binding and downstream cAMP signaling.
Incretins are released by enteroendocrine cells of the gut in response to nutrients — GIP from K cells and GLP-1 from L cells — and the term reflects the observation that oral glucose provokes a larger insulin response than an equivalent intravenous load. Both hormones act on class B G protein-coupled receptors, GIPR and GLP-1R, through the Gs/cAMP pathway.
Native incretins are inactivated within minutes by the protease DPP-4, so engineered research analogs incorporate modifications that resist this cleavage.
Termos relacionados