Para uso exclusivo em pesquisa laboratorial. Não destinado ao consumo humano. Não destinado a uso clínico ou terapêutico. Não avaliado pela FDA.
GLP-1 Receptor
Também conhecido como: GLP-1R
The GLP-1 receptor (GLP-1R) is a class B G protein-coupled receptor that binds glucagon-like peptide-1 and signals through the Gs/cAMP pathway. It is a primary target of incretin-mimetic research peptides.
On agonist binding, GLP-1R couples to the stimulatory G protein Gs, activating adenylyl cyclase and raising cyclic AMP (cAMP), which in turn engages protein kinase A (PKA) and Epac. It can also recruit beta-arrestin, a pathway used to characterize biased agonism in vitro.
GLP-1R is one of the two canonical incretin receptors and is studied in receptor-pharmacology assays.
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