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مقارنة بحثية
MOTS-c مقابل NAD+
MOTS-c and NAD+ belong to different compound classes. MOTS-c is a 16-residue mitochondrial-derived peptide (MRWQEMGYIFYPRKLR; C101H152N28O22S2, 2174.6 g/mol). NAD+ is not a peptide but a dinucleotide redox coenzyme (C21H27N7O14P2, 663.43 g/mol). In vitro, MOTS-c is characterized in cell-signaling assays, while NAD+ serves as an enzyme cofactor in biochemical assays.
| الخاصية | MOTS-c | NAD+ |
|---|---|---|
| Compound class / structure | Mitochondrial-derived peptide (Arg-terminal form) | Dinucleotide redox coenzyme (not a peptide) |
| Sequence | MRWQEMGYIFYPRKLR | None — two nucleotides joined by a pyrophosphate linkage |
| Length (residues) | 16 aa | Not applicable (not a peptide) |
| Heteroatoms of note | Sulfur (two methionine residues) | Phosphorus (pyrophosphate linkage) |
| Molecular formula | C101H152N28O22S2 | C21H27N7O14P2 |
| Molecular weight | 2174.6 g/mol | 663.43 g/mol |
| CAS number | 1627580-64-6 | 53-84-9 |
| In-vitro context | Cell-signaling assays (AMPK pathway) | Cofactor / substrate in enzyme assays (sirtuins, PARPs) |
| Supplied as | Lyophilized powder, 10 mg vial | Lyophilized powder, 500 mg or 1000 mg vial |
| COA on file | Yes (Kovera Labs) | Yes (Kovera Labs) |
الأسئلة الشائعة
Are MOTS-c and NAD+ the same type of compound?+
No. MOTS-c is a 16-residue peptide with a defined amino-acid sequence. NAD+ is a dinucleotide coenzyme with no amino-acid sequence; its formula carries two phosphorus atoms from the pyrophosphate linkage, while MOTS-c carries two sulfur atoms from its methionine residues.
How do their molecular weights and vial fills compare?+
MOTS-c is the heavier molecule at 2174.6 g/mol versus 663.43 g/mol for NAD+. NAD+ is supplied in much larger vial fills than MOTS-c; both are supplied as lyophilized powder.
How are MOTS-c and NAD+ used in vitro?+
MOTS-c is characterized in cell-signaling assays, including AMPK-pathway work. NAD+ is used as a cofactor or substrate in enzyme assays such as sirtuin and PARP activity measurements. Both are for in-vitro laboratory research use only.