Thymosin Beta-4 (Tβ4)

يُعرف أيضًا باسم: Tβ4, TB4

Thymosin beta-4 is a 43-amino-acid endogenous regulatory peptide that binds and sequesters monomeric G-actin, influencing cytoskeletal dynamics and cell migration. TB-500 is a synthetic fragment derived from its actin-binding domain, studied in preclinical models for the same mechanistic pathway.

Research on thymosin beta-4 centers on in-vitro cell-migration assays, with the actin-binding LKKTETQ sequence identified as the region responsible for its activity.