Para uso exclusivo em pesquisa laboratorial. Não destinado ao consumo humano. Não destinado a uso clínico ou terapêutico. Não avaliado pela FDA.
Comparação de pesquisa
PT-141 vs MT-2
PT-141 and MT-2 are cyclic lactam heptapeptides in the melanocortin family with nearly identical structures. The difference is at the C-terminus: MT-2 ends in an amide (C50H69N15O9, 1024.2 g/mol), while PT-141 ends in a free acid (C50H68N14O10, 1025.2 g/mol). Both are characterized in melanocortin-receptor binding assays.
| Atributo | PT-141 | MT-2 |
|---|---|---|
| Peptide class / structure | Cyclic lactam melanocortin peptide | Cyclic lactam α-MSH analog |
| C-terminus | Free acid | Amide |
| Receptor class (binding assays) | Melanocortin receptors (MC3R/MC4R) | Melanocortin receptors, including MC1R |
| Length (residues) | 7 aa (cyclic) | 7 aa (cyclic) |
| Molecular formula | C50H68N14O10 | C50H69N15O9 |
| Molecular weight | 1025.2 g/mol | 1024.2 g/mol |
| CAS number | 189691-06-3 | 121062-08-6 |
| Supplied as | Lyophilized powder, 10 mg vial | Lyophilized powder, 10 mg vial |
| COA on file | Yes (Janoshik Analytical) | Yes (Kovera Labs) |
Perguntas frequentes
How are PT-141 and MT-2 related structurally?+
They share a cyclic lactam heptapeptide core and differ at the C-terminus: MT-2 carries a C-terminal amide and PT-141 a free acid. That single change shows up in the formulas — C50H69N15O9 for MT-2 versus C50H68N14O10 for PT-141.
Why are their molecular weights so close?+
Replacing a C-terminal amide (–NH₂) with a free acid (–OH) changes the mass only slightly: MT-2 is 1024.2 g/mol and PT-141 is 1025.2 g/mol. Because the values are close, check the formula and CAS number (189691-06-3 for PT-141, 121062-08-6 for MT-2) on a Certificate of Analysis to confirm which compound it covers.
Do PT-141 and MT-2 bind the same receptors?+
Both are characterized at melanocortin receptors in binding assays. PT-141 is usually profiled for MC3R/MC4R selectivity, while MT-2 is profiled more broadly across the family, including MC1R.