PT-141

PT-141 is a synthetic cyclic heptapeptide analog of alpha-MSH that acts as a nonselective melanocortin-receptor agonist, with highest affinity at MC4R. It is studied in preclinical research for melanocortin-receptor binding and downstream signaling.

As a synthetic analog, PT-141 resists the rapid enzymatic degradation that limits the endogenous hormone, making it a common reference ligand in melanocortin-receptor binding assays.