For laboratory research use only. Not for human consumption. Not for clinical or therapeutic use. Not evaluated by the FDA.
For laboratory research use only. Not for human consumption. Not for clinical or therapeutic use. Not evaluated by the FDA.
Also known as: GHRP, secretagogue
A growth hormone secretagogue is a compound that stimulates growth-hormone release by acting on the GH secretagogue receptor (GHSR-1a), distinct from GHRH-receptor agonists.
Growth hormone secretagogues are synthetic ghrelin mimetics that bind GHSR-1a on pituitary somatotroph cells. Unlike GHRH-receptor agonists, which signal through Gs and cyclic AMP, the GHSR couples mainly to Gq, triggering phospholipase C, IP3, and intracellular calcium release as its output.
Examples characterized in receptor-pharmacology research include ipamorelin, noted in preclinical work for its selectivity, together with the earlier peptides GHRP-2 and GHRP-6. Because the GHSR and GHRH-receptor pathways are mechanistically distinct, the two classes are frequently examined side by side in studies of growth-hormone-axis regulation.
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