For laboratory research use only. Not for human consumption. Not for clinical or therapeutic use. Not evaluated by the FDA.
For laboratory research use only. Not for human consumption. Not for clinical or therapeutic use. Not evaluated by the FDA.
Also known as: GHRH
GHRH is a hypothalamic hormone that stimulates the pituitary to release growth hormone. GHRH analogs such as CJC-1295 and Tesamorelin are studied for sustained activation of this pathway.
GHRH binds the GHRH receptor, a class B G protein-coupled receptor on pituitary somatotroph cells, coupling to Gs and raising cyclic AMP (cAMP) to drive growth-hormone synthesis and release. Native GHRH has a very short half-life because DPP-4 and other proteases rapidly cleave it.
Synthetic analogs are engineered for greater enzymatic stability: tesamorelin is a stabilized analog of the GHRH(1–44) sequence, while CJC-1295 can carry a drug-affinity-complex (DAC) moiety that binds albumin for extended exposure. These GHRH-receptor agonists are studied in receptor-pharmacology research as a mechanism distinct from secretagogues that act on the GHSR.